ABSTRACT VIEWER

Spectrum of Langerhans Cell Histocytosis with Prognostic Parameters

Swapan Kr Sinha, Sarbani Chattopadhyay, Sharmila Sen, Keya Basu, Aparna Bhattacharyya, Rita Basumitra, Sapnokamal Sengupta

Abstract

Thirteen patients, eight males and five females, age ranging from 10 months to 24 years, presented with solitary lytic lesions in three cases (23%), more than one lytic bone lesions in two cases (15.38%) and disseminated disease with lytic bone lesions, lymphadenopathy, hepatosplenomegaly, endocrinopathy (diabetes insipidus), exophthalmos and skin lesion in eight cases (61.5%). FNA cytology was performed in all the cases and the diagnosis was Langerhans Cell Histiocytosis (LCH). Histological examination  done in seven patients confirmed the diagnosis of LCH. CD 1a was done on tissue sections in four cases and three tested positive. Ten had anaemia (77%), two had leucopenia (15%), three had thrombocytopenia (23%) and one had pancytopenia (7.5%). Bone marrow was aspirated in six cases and involvement was present in two cases (all disseminated form of the disease). Prognostic parameters were evaluated on the basis of clinical, radiological, haematological and histological features.

Journal of Cytology 2004; 21 (2) : 73-76

Keywords : Langerhans cell histiocytosis, LCH, Lytic bone lesions, FNAC