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Discussion Case #3  
 
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Our Reasoning & Report

  • Young Pt

  • Small round cell tumour in retroperitoneum

  • Cells with tails

 

Ganglioneuroblastoma

 
But were the cells really ganglionic cells?
 
   
 

These were malignant blue cells & the cells had cytoplasmic tails but no true ganglionic features

nThey could have been

n   ?  Rhabdomyoblastic cells

n   ? Cells with a rhabdoid phenotype

 

nWhat was the exact imaging location? Suprarenal or Renal

 

nDD should have included:

True Rhabdomyosarcoma?

PNST with rhabdomyoblastic differentiation?

nWilm’s tumour with  rhabdomyoblastic differentiation

 

  
     
   
     
   
     
 
  • nThe clinical details and anatomic site is important
  • nThe entire DD of round cells must be considered
  • nBut finally what matters is the correct clinical context and the cell cytology
 
     
  Diagnosis

Wilm’s Tumour with Rhabdomyoblastic Differentiation